HM2 High-Mass Systems 
Publications
Peer Reviewed Articles using CovalX's technology
- Compelling Advantages of Negative Ion Mode Detection in High-Mass MALDI-MS for Homomeric Protein Complexes. Madler, S et al., JASMS, 2012, 23(2), 213-224. more...
- A Specific Protein Disorder Catalyser of HIV-1 Nef. Lugari, A et al., Bioorganic & Medicinal Chemistry, 2011, 19, 7401-7406. more...
- The Structural Basis For Increased Toxicity of Pathological AB42:AB40 Ratios in Alzheimer's Disease. Pauwels, K et al., Journal of Biological Chemistry, 2011, jbcM111.264473. more...
- Does Chemical Cross-Linking with NHS Esters Reflect the Chemical Equilibrium of Protein-Protein Noncovalent Interactions in Solution? Mädler, S et al., JASMS; 2010, Vol 21, No. 10, pp 1775-1783. more...
- MALDI imaging and profiling MS of higher mass proteins from tissue. van Remoortere, A et al. JASMS; 2010, Vol 21, No. 11, pp 1922-1929. more...
- MALDI linear TOF mass spectrometry of PEGylated (glyco)proteins. Seyfried, B et al. Journal of Mass Spectrometry, 2010, Vol. 46, Iss. 6, pp 612-617, June 2010. more...
- Detection of Nucleic Acid-Nuclear Hormone Receptor complexes with mass spectrometry. Bich, C et al. JASMS; 2010, 21, 635-645. more...
- Biochemical and Biophysical characterization of the Mg2+ induced 90 kDa heat shock protein oligomers. Moullintraffort, L et al. Journal Biological Chemistry, 2010, JBC, May 14th 2010. more...
- Reactivity and Applications of New Amine Reactive Cross-Linker for Mass Spectrometry Detection of Protein Complexes. Bich, C et al. Anal. Chem., 2010, 82 (1), pp 172–179. more...
- Probing the Hydrophobic Effect of Noncovalent Complexes by Mass Spectrometry. Bich, C et al. JASMS, 2010, 21(2) 286-289. more...
- Mass spectrometry of large complexes. Bich, C. and R. Zenobi, Current Opinion in Structural Biology, 2009, 19, 1-8. more...
- Characterization of high molecular weight multimeric states of human haptoglobin and hemoglobin-based oxigen carriers by high-mass MALDI MS. Pimenova, T. et al. J. Sep. Sci. 2009, 32, 1224-1230. more...
- Towards high-throughput identification of endocrine disrupting compounds with mass spectrometry. Bovet, C. et al. Toxicology in Vitro; 2009, 23, 4, 704-709. more...
- Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor. Michel F et al. The EMBO Journal; 2009, 28, 980-991. more...
- The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways. Vallelian F et al. Free Radical & Medicine 45 (2008) 1150-1158. more...
- Monitoring Ligand Modulation of Protein-Protein Interactions by Mass Spectrometry: Estrogen Receptor r-SRC1. Bovet C. et al. Anal. Chem., 80, (2008), 7833–7839. more...
- Structural properties of AMP-activated protein kinase. Dimerization, molecular shape, and changes upon ligand binding. Riek U et al. J. Biol. Chem; June 27 2008; Vol. 283, No. 26, pp. 18331–18343, more...
- Structural Characterization of human general transcription factor TFIIF in solution. Akashi S et al. Protein Science; 2008; 17: 389–400. doi: 10.1110/ps.073258108. more...
- Characterization of antibody-antigen interactions: Comparison between surface plasmon resonance measurements and high-mass matrix assisted laser desorption/ionization mass spectrometry. Bich C et al. Anal. Biochem.; 2008; 375:35-45. more...
- Epitope mapping on bovine prion protein using chemical cross-linking and mass spectrometry. Pimenova et al. J. Mass Spectrom.; 2008; 43:185-195. more...
- Proteomic Profiling of a Snake Venom Using High Mass Detection MALDI-TOF Mass Spectrometry - Yanes O et al. JASMS; 2007; 18(4); 600-606. more...
- Detection of non-covalent complexes in biological samples by intensity fading and high-mass detection MALDI ToF mass spectrometry. Yanes O et al. J. Proteom. Research; 2006; 5:10; 2711-2719. more...
- Immunoassays with direct mass spectrometric detection. Nazabal et al. Anal. Chem.; 2006; 78(11); 3562-3570. more...
Oral and Poster presentations
ABRF 2010 Conference, March 20-23, 2010, Sacramento, California, USA
MIRG2010 Benchmark Study: Molecular Interactions in a Three Component System. Simon Bergqvist, Mike Doyle, Ed Eisenstein, Matthew Robinson, Satya Yadav, Aaron Zamniuk, Tony Yeung
HUPO Conference, Oct 6-10, 2007, Seoul, S. Korea
SFSM Conference, Sept 17-20, 2007, Pau, France
ASMS Conference, June 3-7, 2007, Indianapolis, USA
Alexis Nazabal and Ryan Wenzel
Quantitative comparison of sensitivity and saturation for MALDI-TOF detectors when measuring complex and high mass samples Ryan J. Wenzel, Susanne Kern, Alexis Nazabal and Renato Zenobi
Epitope mapping on bovine prion protein using chemical cross-linking and mass spectrometry
Tatiana Pimenova; Alexis Nazabal; Bernd Roschitzki; Jan Seebacher; Oliver Rinner; Renato Zenobi
Characterization of Monoclonal Antibodies: Surface Plasmon Resonance or Highmass MALDI Mass Spectrometry?
Claudia Bich, Alexis Nazabal, Ryan Wenzel, Mike Scott and Renato Zenobi
(Oral) Intact estrogen receptor complexes measured by chip-based nanoelectrospray and MALDI mass spectrometry: an approach to identify and classify endocrine disruptors Cédric Bovet; Arno Wortmann; Marc Ruff; Sylvia Eiler; Florence Granger; Alexis Nazabal; Ryan Wenzel; Bertran Gerrits; Dino Moras; Renato Zenobi
MSSJ Conference, May 15-17, 2007, Hiroshima, Japan (Oral) Structure Analysis of Human Transcription Factor TFIIF in Solution S. Nagakura, S. Yamamoto, Y. Ohkuma, Y. Nishimura, S. Akashi
ABRF Conference, April 2-5, 2007, Tampa, USA
USGEB Computational Biology Conference, March 13-14, 2007, Basel, Switzerland
ASMS Conference, June 2-6, 2006, Seattle, USA
Super-Shifting: A new method for the analysis of protein complexes using High-Mass MALDI ToF mass spectrometry Alexis Nazabal, Markus Schlumberger, Wolf Dietrich Hardt and Renato Zenobi
Comparison of Sensitivity and Saturation of MALDI-TOF Detectors for High Mass Ions Ryan J. Wenzel, Susanne Kern and Renato Zenobi
