HM2 and HM2 TUVO High-Mass Systems



The analysis of intact protein complexes by MALDI mass spectrometry requires a special high-mass detection system. CovalX introduces its next generation of High-Mass systems based on unique conversion dynode technology. HM2 and HM2 TUVO High-Mass systems allow unmatched detection of macromolecular ions up to 1.2 MDa with nM sensitivity. The HM2 system is the new reference for the detection of high molecular weight macromelcules. HM2 TUVO offers the same features of HM2 with an additional capability to analyse ions in both positive and negative mode.  

HM2 and HM2 TUVO High-Mass systems are available for every standard MALDI ToF mass spectrometers:

 

  • Applied Biosystems: 5800, 4800, Voyager series (DE Pro, DE STR).
  • Bruker: Biflex, Reflex, Autoflex and Ultraflex series.
  • Shimadzu Kratos: Axima series.

 

CovalX Ipod Touch Controller for HM2 and HM2 TUVO. CovalX's HM2 and HM2 TUVO are controlled wirelessly using the CovalX's IPod Touch application. To switch between High-Mass detection and standard detection or between positive and negative ion detection modes (TUVO), simply press a button on the touch screen of your CovalX's IPod controller.

CovalX HM2  High-Mass Systems does not change any of the previous features of your MALDI ToF instrument. After retrofit, the standard detector in the linear mode is not removed. The operator can choose between high mass detection and normal detection in few seconds simply by pressing a button on the touch screen of CovalX's iPod Touch controller.

To learn more about CovalX's iPod Touch application please see our support page.

With CovalX HM2 High-Mass Systems you can have access to the following applications:

 

 HM2 High-Mass systems allows one to reach outstanding sensitivity for high-molecular weight macromolecules and complex mixture of proteins. 

For more information concerning HM2 High-Mass retrofit for your MALDI ToF intrument, please contact our Customer Support Centers.

 

High-Mass MALDI ToF mass spectra of the immunoglobulin IgM (300 nM). The mono-charged pseudo-molecular ions of IgM are detected with m=973.26 kDa.

HM2 TUVO High-Mass System retrofit on ABI MALDI ToF/ToF 5800. More information...